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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TTK All Species: 21.82
Human Site: T805 Identified Species: 40
UniProt: P33981 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P33981 NP_003309.2 857 97072 T805 V N Q M A K G T T E E M K Y V
Chimpanzee Pan troglodytes XP_001146752 857 97034 T805 G N Q M A K G T T E E M K Y V
Rhesus Macaque Macaca mulatta XP_001111082 778 87619 A727 I S I P E L L A H P Y V Q I Q
Dog Lupus familis XP_539016 855 96614 T802 G N Q M A K G T T E E M K Y V
Cat Felis silvestris
Mouse Mus musculus P35761 856 96192 A804 G S Q M A R G A T D E M K Y V
Rat Rattus norvegicus NP_001101642 835 94323 T783 G S Q M A K E T T D E M K Y M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512474 935 104827 T816 Q P G K A K E T S E E M K R V
Chicken Gallus gallus XP_419867 879 99691 A825 G V A N A K G A T E E V K R I
Frog Xenopus laevis NP_001082090 882 99060 T828 D Q Q V Q K E T T E E M K R I
Zebra Danio Brachydanio rerio Q8AYG3 982 109993 S930 A P E P A E T S S S D F K R I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002301009 818 91361 G763 L V S E T C S G D Q E A S V L
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_565160 777 86358 M726 D D D K A N S M I S Q L E Q L
Baker's Yeast Sacchar. cerevisiae P54199 764 86809 S713 T V D K V L S S T F L Q P F M
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 85.7 87.4 N.A. 74.3 76.9 N.A. 64.2 61 52.8 41.4 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.6 87.7 92.6 N.A. 84.8 85.6 N.A. 73.6 74.5 68.4 57 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 93.3 0 93.3 N.A. 66.6 66.6 N.A. 53.3 46.6 53.3 13.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 93.3 26.6 93.3 N.A. 86.6 86.6 N.A. 60 60 66.6 53.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: 23.1 N.A. N.A. 22.9 22.7 N.A.
Protein Similarity: 40.2 N.A. N.A. 42.3 44.5 N.A.
P-Site Identity: 6.6 N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: 26.6 N.A. N.A. 40 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 8 0 70 0 0 24 0 0 0 8 0 0 0 % A
% Cys: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % C
% Asp: 16 8 16 0 0 0 0 0 8 16 8 0 0 0 0 % D
% Glu: 0 0 8 8 8 8 24 0 0 47 70 0 8 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 8 0 8 0 8 0 % F
% Gly: 39 0 8 0 0 0 39 8 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % H
% Ile: 8 0 8 0 0 0 0 0 8 0 0 0 0 8 24 % I
% Lys: 0 0 0 24 0 54 0 0 0 0 0 0 70 0 0 % K
% Leu: 8 0 0 0 0 16 8 0 0 0 8 8 0 0 16 % L
% Met: 0 0 0 39 0 0 0 8 0 0 0 54 0 0 16 % M
% Asn: 0 24 0 8 0 8 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 16 0 16 0 0 0 0 0 8 0 0 8 0 0 % P
% Gln: 8 8 47 0 8 0 0 0 0 8 8 8 8 8 8 % Q
% Arg: 0 0 0 0 0 8 0 0 0 0 0 0 0 31 0 % R
% Ser: 0 24 8 0 0 0 24 16 16 16 0 0 8 0 0 % S
% Thr: 8 0 0 0 8 0 8 47 62 0 0 0 0 0 0 % T
% Val: 8 24 0 8 8 0 0 0 0 0 0 16 0 8 39 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 8 0 0 39 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _